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About Dr. Jessica Cooke Bailey

Our research takes a comprehensive approach to integrate trans-ancestral genomic and health data to dissect the genetic and non-genetic mediators of POAG. I hope to characterize and quantify clinical, lifestyle, environmental, and genetic differences across diverse groups, determine how genetic ancestry mediates genomic risk, and build models to effectively translate risk information to clinical, individual, and community stakeholders.

Research Interests

Moving beyond the knowledge we have gained from extensive genome-wide association studies and mega meta-analyses primarily in populations of European descent, the research of Team Cooke Bailey will integrate trans-ethnic genomic and health data to dissect the genomic and environmental aspects of glaucoma.

Our overall research goal is to better understand the complexity of POAG risk by assessing differences across ethnic groups to illuminate undetected genetic and non-genetic mediators. In addition, we aim to:

  1. Characterize and quantify clinical, lifestyle, environmental, and genetic differences in POAG patients within and across ethnic groups to illuminate potential mediators of POAG risk.

  2. Understand how African ancestry mediates genomic risk for POAG.

  3. Characterize POAG in the Amish and study genetic factors related to this disease to elucidate novel variations potentially contributing to POAG and other POAG-relevant endophenotypes.

  4. Assimilate data across multiple entities to disentangle the genetics and genomic interactions that contribute to POAG, aiming to translate the knowledge gained into clinically relevant information.

Education

2012

Wake Forest University 

PhD, Molecular Medicine and Translational Science 

2018

Case Western Reserve University

2008

Winthrop University

Master of Arts, Bioethics 

Bachelors of Science, Biology 

Fellowships

2013

Postdoctoral Fellow, Case Western Reserve University

Postdoctoral Fellow, Vanderbilt University

2012

Professional Memberships

American Society for Human Genetics

Association for Research in Vision and Opthalmology

National Association of Professional Women 

Contributions to Science 

  • Applied meta-analysis and targeted, hypothesis-driven approaches, identifying nine primary open-angle glaucoma (POAG) risk loci. 

  • Explored intraocular pressure, corneal thickness and optic disc morphology to elucidate genetic contributors to POAG-related quantitative traits and endophenotypes to better understand POAG genetic risk.

  • Applied pathway-based analyses to GWA data, identifying several biological pathways and/or gene sets influencing POAG, highlighting novel mechanisms affecting disease susceptibility.

  • Evaluated genome-wide data from the largest primary open-angle glaucoma case-control analysis to data at that time, identifying three primary open-angle glaucoma genetic risk loci.

  • Evaluated exome data in one of the largest AMD studies to date, identifying rare and common variation, to better understand genetic contributors to AMD. 

  • Applied genetic risk scores to understand common, complex diseases including glaucoma and type 2 diabetes.

Call 

123-456-7890 

Email 

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